| CD220 Gene ID | 3643 |
| CD220 Official Full Name | insulin receptor |
| CD220 Alias | Insulin-R, Insulin Receptor, IINSR |
| CD220 Cellular Expression | T; B; NK; Dendritic; Endothelial; Epithelial; Granulocyte; Macrophage; Stem cell |
| CD220 Ligand/Receptor/Association | insulin |
| CD220 Function | Insulin receptor |
| CD220 Summary | The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors.[1] Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis, a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer.[2][3] Biochemically, the insulin receptor is encoded by a single gene INSR, from which alternate splicing during transcription results in either IR-A or IR-B isoforms.[4] Downstream post-translational events of either isoform result in the formation of a proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ≈320 kDa disulfide-linked transmembrane insulin receptor.[4] |
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