CD227 antigens

CD227 antigens general information

CD227 Gene ID 4582
CD227 Official Full Name mucin 1, cell surface associated
CD227 Alias MUC1, EMA, PUM, Mucin 1
CD227 Cellular Expression T; B; Dendritic; Epithelial; Macrophage; monocytes; Stem cell
CD227 Ligand/Receptor/Association CD54, CD169, selectins
CD227 Function Cell adhesion and signaling
CD227 Summary This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Information from NCBI or Wiki

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