| CD272 Gene ID | 208154 |
| CD272 Official Full Name | B and T lymphocyte associated |
| CD272 Alias | BTLA |
| CD272 Cellular Expression | T; B; Dendritic; Macrophage |
| CD272 Ligand/Receptor/Association | HVEM |
| CD272 Function | Lymphocyte inhibitory receptor |
| CD272 Summary | BTLA (B- and T-lymphocyte attenuator); expression induced during activation of T cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 (CD279) and CTLA-4 (CD152), BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a ligand for HVEM (CD270). BTLA-HVEM complexes negatively regulate T-cell immune responses. BTLA activation inhibits the function of CD8+ cancer-specific T cells. |
Information from NCBI or Wiki
