CD274 antigens

CD274 antigens general information

CD274 Gene ID 29126
CD274 Official Full Name CD274 molecule
CD274 Alias B7-H1, PD-L1
CD274 Cellular Expression T; B; NK; Dendritic; Epithelial; Granulocyte; Macrophage
CD274 Ligand/Receptor/Association PD-1
CD274 Function Found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition
CD274 Summary This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Information from NCBI or Wiki

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