CD299 antigens

CD299 antigens general information

CD299 Gene ID 10332
CD299 Official Full Name C-type lectin domain family 4 member M
CD299 Cellular Expression Endothelial; Erythrocyte
CD299 Ligand/Receptor/Association ICAM-3, HIV gp120, Hepatitis C virus, ebolavirus
CD299 Function Pathogen-recognition receptor involved in peripheral immune surveillance in liver. Recognizes mannose N-linked oligosaccharides in HIV-1, HIV-2, human cytomegalovirus and human SARS coronavirus
CD299 Summary This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

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