CD304 antigens

CD304 antigens general information

CD304 Gene ID 8829
CD304 Official Full Name neuropilin 1
CD304 Alias BDCA4, neuropilin 1, CLEC4C, NRP1
CD304 Cellular Expression T; Dendritic; Endothelial
CD304 Ligand/Receptor/Association VEGF165, SEMA3A, complexed with plexin-1
CD304 Function Angiogensis, axon guidance, cell survival, migration, and invasion
CD304 Summary This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Information from NCBI or Wiki

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