CD324 antigens

CD324 antigens general information

CD324 Gene ID 999
CD324 Official Full Name cadherin 1
CD324 Alias E-Cadherin, Uvomorulin, CDH1, E-cad
CD324 Cellular Expression Epithelial; Erythrocyte; Platelet; Stem cell
CD324 Ligand/Receptor/Association CD103, E-cadherin, PS1, catenins, internalin
CD324 Function Calcium-dependent cell adhesion protein
CD324 Summary This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

Information from NCBI or Wiki

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