CD325 antigens

CD325 antigens general information

CD325 Gene ID 12558
CD325 Official Full Name cadherin 2
CD325 Alias N-Cadherin, NCAD, CDH2
CD325 Cellular Expression Epithelial; Stem cell
CD325 Ligand/Receptor/Association N-cadherin, catenins, FGFR, PS1
CD325 Function In hippocampal cells, pancreatic cells and hepatocytes
CD325 Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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