CD334 antigens

CD334 antigens general information

CD334 Gene ID 2264
CD334 Official Full Name fibroblast growth factor receptor 4
CD334 Alias FGFR4, JTK2, TKF
CD334 Cellular Expression Epithelial; Macrophage
CD334 Ligand/Receptor/Association aFGF, FGF19
CD334 Function Cell-surface receptor for fibroblast growth factors
CD334 Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Information from NCBI or Wiki

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