CD352 antigens

CD352 antigens general information

CD352 Gene ID 114836
CD352 Official Full Name SLAM family member 6
CD352 Alias NTB-A, SLAMF6, LY108
CD352 Cellular Expression T; B; NK; Dendritic; Granulocyte; Macrophage
CD352 Ligand/Receptor/Association CD352
CD352 Function Triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors
CD352 Summary The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Information from NCBI or Wiki

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