CD49c antigens

CD49c antigens general information

CD49c Gene ID 3675
CD49c Official Full Name integrin subunit alpha 3
CD49c Alias VLA-3, ITGA3
CD49c Cellular Expression T; B; Endothelial; Epithelial; Macrophage; Platelet
CD49c Ligand/Receptor/Association collagen, laminin-5, fibronectin
CD49c Function Adhesion and signal transduction
CD49c Summary The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]

Information from NCBI or Wiki

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