CD49e antigens

CD49e antigens general information

CD49e Gene ID 3678
CD49e Official Full Name integrin subunit alpha 5
CD49e Alias VLA-5, ITGA5
CD49e Cellular Expression T; B; NK; Dendritic; Endothelial; Epithelial; Erythrocyte; Macrophage; monocytes; Platelet; Stem cell
CD49e Ligand/Receptor/Association fibronectin, invasin
CD49e Function Adhesion, regulation of cell survival and apoptosis
CD49e Summary The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

Information from NCBI or Wiki

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