| CD49e Gene ID | 3678 |
| CD49e Official Full Name | integrin subunit alpha 5 |
| CD49e Alias | VLA-5, ITGA5 |
| CD49e Cellular Expression | T; B; NK; Dendritic; Endothelial; Epithelial; Erythrocyte; Macrophage; monocytes; Platelet; Stem cell |
| CD49e Ligand/Receptor/Association | fibronectin, invasin |
| CD49e Function | Adhesion, regulation of cell survival and apoptosis |
| CD49e Summary | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015] |
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