CD49f antigens

CD49f antigens general information

CD49f Gene ID 3655
CD49f Official Full Name integrin subunit alpha 6
CD49f Alias VLA-6, ITGA6
CD49f Cellular Expression T; Endothelial; Epithelial; Macrophage; monocytes; Platelet; Stem cell
CD49f Ligand/Receptor/Association laminins, invasin
CD49f Function Embryogenesis, adhesion and cell migration
CD49f Summary The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

Information from NCBI or Wiki

Tips: We list all the CD antigens according to the specific name of CD molecules.