CD59 antigens

CD59 antigens general information

CD59 Gene ID 966
CD59 Official Full Name CD59 molecule
CD59 Alias Protectin, MAC- inhibitor
CD59 Cellular Expression T; NK; Erythrocyte; Granulocyte; Macrophage
CD59 Ligand/Receptor/Association C8a, C9
CD59 Function Prevents complement polymerization. Protects cells from complement mediated lysis
CD59 Summary CD59 glycoprotein also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene.[1]CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex.[2] Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria.[3]Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.[4

Information from NCBI or Wiki

Tips: We list all the CD antigens according to the specific name of CD molecules.