CD62L antigens

CD62L antigens general information

CD62L Gene ID 6402
CD62L Official Full Name selectin L
CD62L Alias L-selectin, LECAM-1, SELL
CD62L Cellular Expression T; B; NK; Granulocyte; Macrophage; monocytes
CD62L Ligand/Receptor/Association CD34, MAdCAM-1, GlyCAM-1, CD57, CD15su
CD62L Function Leukocyte rolling and homing on activated endothelium
CD62L Summary This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Information from NCBI or Wiki

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