CD64 antigens

CD64 antigens general information

CD64 Gene ID 14129
CD64 Official Full Name Fc receptor, IgG, high affinity I
CD64 Alias FcγRI, FCGR1, FCGR1A
CD64 Cellular Expression Dendritic; Macrophage; monocytes
CD64 Ligand/Receptor/Association IgG
CD64 Function Innate and adaptive immune responses
CD64 Summary CD64 (Cluster of Differentiation 64) is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity.[1] It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation.[2]Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail.[3]CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.[4][5]There are three distinct (but highly similar) genes in humans for CD64 called FcγRIA (CD64A), FcγRIB (CD64B), and FcγRIC (CD64C) that are located on chromosome 1.[6] These three genes produce six different mRNA transcripts ; two from CD64A, three from CD64B, and one from CD64C; by alternate splicing of the genes.[3]

Information from NCBI or Wiki

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