CD66a antigens

CD66a antigens general information

CD66a Gene ID 634
CD66a Official Full Name carcinoembryonic antigen related cell adhesion molecule 1
CD66a Alias BGP-1, NCA-160, CEACAM1
CD66a Cellular Expression Epithelial; Granulocyte
CD66a Ligand/Receptor/Association CD66a, c, e, CD62E, Opa
CD66a Function Neutrophil activation, homophilic and heterophilic adhesion
CD66a Summary This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

Information from NCBI or Wiki

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