CD85d antigens

CD85d antigens general information

CD85d Gene ID 10288
CD85d Official Full Name leukocyte immunoglobulin like receptor B2
CD85d Alias LILRB2, ILT4, LIR2, MIR10
CD85d Cellular Expression Dendritic; Granulocyte; Macrophage; monocytes
CD85d Ligand/Receptor/Association  
CD85d Function Down regulates the immune response and involved in the development of tolerance
CD85d Summary This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

Information from NCBI or Wiki

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