Sino biological offers a comprehensive set of tools for CD antigens related to cell adhesion research, including recombinant proteins, antibodies (mouse mAbs, rabbit mAbs, and rabbit pAbs), ELISA kits, and ORF cDNA clones.
The B7 family protein is present on the antigen-presenting cell surface, and it interacts with the CD28 receptor on the T cell surface. There are two major types of B7 proteins: B7-1/CD80, and B7-2/CD86. This interaction produces a series of downstream signals which promote the target T cell's survival and activation. Blockade of CD28 is effective in stopping T cell activation. T cells can express the surface protein CD152 as well, which can also bind B7. Binding of the B7 on T-cells to CD152 causes inhibition of the activity of T-cells. As a result, the T cell is blocked from receiving the B7 protein signal and is not activated.