Human Leukocyte Differentiation Antigen workshop Ⅱ/ HLDA2

The Human Leukocyte Differentiation Antigen workshop Ⅱ (HLDA2), held in Boston, USA, in 1984. The purpose of HLDA2 was to continue to define clusters of antibodies identifying myeloid-associated antigens. This workshop also examined antibodies thought to react with natural killer (NK) cells, and with a group of heterodimeric molecules associated with specific leukocyte functions and referred to as the LFA family.

One hundred and twenty antibodies were submitted by 41 laboratories in the form of ascites fluid in most cases. Of these, four were of insufficient quantity to be analyzed and 116 antibodies were analyzed in detail, two of which were withdrawn. Each participating laboratory evaluated the panel of antibodies using one or more of the six myeloid protocols. In addition, CD antigens thought to have anti-NK and LFA activity were designated. The results of serologic and cluster analysis will be discussed later in this chapter, while data obtained from functional, biochemical, and phylogeny studies will be presented in individual reports in this volume.

New CD antigens list of HLDA2

Name Alias Function
CD16a FcγRIIIA, FCGR3A, FCG3, FCGR3, IGFR3 Low affinity Fc receptor. Mediates phagocytosis and antibody-dependent T-cell-mediated cytotoxicity
CD16b FcγRIIIB, FCGR3B, FCG3, FCGR3, IGFR3 Low affinity Fc receptor
CD18 Integrin β2, ITGB2, MFI7 Adhesion, cell signaling
CD19 B4, Leu-12 Regulates B-cell development, activation and differentiation. Signal transduction
CD20 B1, Bp35, MS4A1 B-cell activation and proliferation
CD21 C3DR, CR2, EBV-R Signal transduction. Regulator of complement activation
CD22 BL-CAM, Siglec-2, Leu-14 B-cell adhesion and signal transduction
CD23 FcεRII, BLAST-2, FCER2, CLEC4J Low affinity receptor for IgE, ligand for CD19, CD21 and CD81. Key molecule for B-cell activation and growth
CD24 BA-1, Nectadrin Regulation of B-cell proliferation and differentiation
CD25 Tac, p55, IL2RA Receptor for IL2
CD26 DPP IV, DPP4, ADABP, ADCP2 Exoprotease. HIV pathogenesis