CD antigens as ligands

CD antigens are an extremely diverse series of leukocyte surface proteins, used as cell markers, and found in various immune cell populations like B cells, thymocytes and T cells. CD antigens serve as receptors and ligands, and regulate cell signalling, cell adhesion and adaptive immunity. CD antigens are utilized in cell sorting techniques and cell populations are usually defined as either positive or negative, to indicate whether or not the cell fraction expresses a particular CD molecule. High-quality monoclonal antibodies against the CD markers allow researchers to easily examine cellular signalling events in complex cell populations and are commonly used for immunology, cancer and stem cell biology research.

The concept of the receptor-ligand interaction is one of the most basic in all of biology. It is a key element to the functioning of all biological systems. It allows neighboring and distant cells to communicate with each other. One cell may have a receptor in its membrane and when it binds to a matching ligand on a neighboring cell the receptor performs some action. Typically this action is to take an existing protein and modify it in some way to either activate or deactivate it. A good example of this is a tyrosine kinase receptor. When this receptor binds to a ligand it becomes activated and can phosphorylate other proteins and activate them. Those proteins can then go on to perform a number of different functions. So cell A that expressed the ligands on its surface was able to communicate with cell B that had the receptors and cause cell B to alter its behavior. The activated proteins inside B could go on to alter gene expression or modify other proteins. This communication is the basic purpose behind the receptor/ligand interactions.

CD antigens chart as ligands

Name Alias Receptor or other
CD2 T11, LFA-2, SRBC-R, Erythrocyte receptor, LFA-3R acts as a ligand for CD58 and CD59 and is involved in signal transduction and cell Adhesion
CD5 T1, Tp67, LEU1 ligand for CD72
CD23 FcεRII, BLAST-2, FCER2, CLEC4J Low affinity receptor for IgE, ligand for CD19, CD21 and CD81
CD27 T14, TNFRSF 7, CD27L receptor TNF-Receptor Binds to ligand CD70
CD36 GPIV, GP3B, GP4, SCARB3 CD36 binds many ligands including collagen
CD39 NTPDase 1, ENTPD1 NTPDase1 hydrolyzes P2 receptor ligands
CD40 TNFRSF5 CD40 combines with its ligand CD154 (CD40L)
CD44 H-CAM, Pgp-1, Epican, HUTCH-I, LHR, ECMR-III CD44 is a receptor for hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs).
CD47 IAP, MER6 binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα)
CD58 LFA-3 ligand for CD2
CD62E E-selectin, ELAM-1, SELE binds to sialylated carbohydrates present
CD62P P-selectin, PADGEM, SELP, LECAM3 The primary ligand for P-selectin
CD70 Ki-24, CD27L, TNFSF7 Its ligand is CD27.
CD72 Lyb-2, Ly-19, Ly-32 a ligand for CD5
CD80 B7, B7-1, BB1 It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4
CD85j LILRB1, ILT2, LIR1 Inhibits cytotoxicity in NK and T cells upon ligand binding
CD86 B70, B7-2, CD28LG2 It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4
CD91 LRP1,A2MR,APOER ligands including amyloid precursor protein (APP), ApoE
CD95 Apo-1, FASLG, APTL, TNFRSF6 Receptor for Fas ligand (CD178 - FASLG
CD96 TACTILE CD96 main ligand is CD155
CD106 VCAM-1, L1CAM Alpha 4 beta 1 ligand
CD107a LAMP-1 Provides selectins with carbohydrate ligands
CD107b LAMP-2 Provides selectins with carbohydrate ligands
CD114 GCSFR, CSF3R CD114 is a protein that in humans is encoded by the CSF3R gene. The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.
CD115 M-CSFR, c-fms, CSF1R Binding to CSF1 and IL34 ligands activate CSF1R
CD130 IL-6Rβ, gp130, IL6ST It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand.
CD132 IL2RG, Common γ The γc chain partners with other ligand-specific receptors to direct lymphocytes to respond to cytokines including IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.
CD134 OX-40, TNFRSF4 its ligand OX40L, or CD252, binds to OX40 Receptors on T-cells
CD135 Flt3, Flk2 Flt3 ligand
CD136 MSP-R, RON, PTK8, MST1R binds to MST1 ligand;
CD153 CD30L, TNFSF8 CD153 is a ligand for CD30.
CD154 CD40L, CD40 Ligand, gp39, TRAP The ligand for CD40
CD161 NKR-P1A, KLRB1 a functional ligand.
CD162 PSGL-1, SELPLG P-selectin glycoprotein ligand 1
CD166 ALCAM ligand for CD6 and involved in neurite extension
CD172a SIRPα, SHPS-1, SIRPA SIRP α recognize CD47
CD178 FasL, CD95L, FASLG, Fas Ligand Fas ligand (FasL)
CD191 CCR1, MIP-1αR, RANTES-R This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1).
CD196 CCR6, BN-1, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22 Binds to MIP-3-alpha/LARC
CD202b Tie2, Tek The ligand for the Receptor is angiopoietin-1.
CD220 Insulin-R, Insulin Receptor, IINSR The insulin Receptor (INSR) is a transmembrane Receptor with intrinsic tyrosine kinase activity whose ligand is insulin
CD230 Prion protein, PRNP an elusive ligand-protein
CD242 ICAM-4 Ligand for the leukocyte Adhesion protein LFA-1
CD244 2B4, NAIL Modulation of other receptor-ligand interactions to enhance leukocyte Adhesion and NK-cytolytic activity
CD252 OX40L, gp34 Ligand for receptor TNFRSF4
CD253 TRAIL, Apo-2L, TL2, TNFSF10 TRAIL (TNF-related apoptosis-inducing ligand)
CD254 TNFSF11, RANKL, OPGL, ODF RANKL (Receptor activator of nuclear factor kappa-B ligand)
CD256 APRIL, TALL-2, TRDL-1, TNFSF13 APRIL (proliferation-inducing ligand)
CD257 BLyS, BAFF, TALL-1, TNFSF13B BAFF is a ligand for Receptors TNFRSF13B/TACI (CD267), TNFRSF17/BCMA (CD269), and TNFRSF13C/BAFF-R (CD268)
CD265 RANK, TRANCE-R, ODFR, TNFRSF11A RANK (Receptor Activator of Nuclear Factor κ B) is the Receptor for RANK-Ligand (RANKL).
CD266 TWEAK-R, FGF-inducible 14, TNFRSF12A TNFRSF12A (Tumor necrosis factor Receptor superfamily member 12A), or Tweak-Receptor (TweakR). Receptor for TWEAK ligand.
CD267 TACI, TNFR SF13B, TNFRSF13B TACI recognizes three ligands: APRIL (CD256), BAFF (CD257) and CAML
CD270 HveA, TR2, TNFRSF14 a human cell surface Receptor of the TNF-Receptor superfamily
CD272 BTLA ligand for HVEM
CD273 B7DC, PD-L2, PDCD1L2 Ligand for PD-1 (CD279)
CD274 B7-H1, PD-L1 Ligand for PD1 (CD279) and also CD80 (B7-1)
CD275 B7-H2, ICOSL, B7-RP1, GL50 Ligand for CD278
CD279 PD1, SLEB2 cell surface Receptor which binds to PD-L1 and PD-L2 ligands
CD284 TLR4 Toll-like Receptor 4 (TLR4 or TOLL)
CD295 LeptinR, LEPR, OB-R, Leptin Receptor a single-transmembrane-domain receptor of the cytokine receptor family
CD314 NKG2D, KLRK1 NKG2D ligands are induced-self proteins
CD322 JAM-B, JAM-2, VE-JAM Acts as an adhesive ligand
CD331 FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM FGFR1 (Fibroblast growth factor Receptor 1) whose ligands are specific members of the fibroblast growth factor family
CD332 FGFR2, BEK, KGFR FGFR1 (Fibroblast growth factor Receptor 1) whose ligands are specific members of the fibroblast growth factor family
CD333 FGFR3, ACH, CEK2 FGFR1 (Fibroblast growth factor Receptor 1) whose ligands are specific members of the fibroblast growth factor family
CD334 FGFR4, JTK2, TKF FGFR1 (Fibroblast growth factor Receptor 1) whose ligands are specific members of the fibroblast growth factor family
CD339 Jagged-1, JAG1, JAGL1, hJ1 Ligand for multiple Notch receptors
CD340 ERBB2, MLN 19 Binds tightly to other ligand-bound EGF receptor family
CD357 TNFRSF18, GITR Human activation-inducible tumor necrosis factor receptor (AITR) and its ligand, AITRL
CD360 IL-21R IL21R (Interleukin 21 Receptor is a cytokine Receptor for interleukin 21 (IL21)