CD antigens are cells surface proteins as receptors. The CD antigens interaction are fundamental to cell signaling. Signal transduction is the process by which a cell recognizes changes in its environment and transforms that signal into modifications in cellular activity and gene expression. Cells receive information through a class of proteins known as receptors. When such CD antigen activate its receptor, the signal is carried into the cell usually by means of a second messenger.
Sino biological offers a comprehensive set of tools for CD antigens related to cell adhesion research, including recombinant proteins, antibodies (mouse mAbs, rabbit mAbs, and rabbit pAbs), ELISA kits, and ORF cDNA clones.
| Name | Alias | Function |
|---|---|---|
| CD1b | T6 | Antigen presenting protein |
| CD1d | R3G1 | Antigen presenting protein |
| CD2 | T11, LFA-2, SRBC-R, Erythrocyte receptor, LFA-3R | Adhesion between T-cells and other cell types and T-cell activation. |
| CD3d | T3D, IMD19, CD3-DELTA | T-cell activation signaling and regulation of TCR expression |
| CD3e | T3E, TCRE, CD3 epsilon | T-cell activation signaling and regulation of TCR expression |
| CD3G | T3G, IMD17, CD3-GAMMA | T-cell activation signaling and regulation of TCR expression |
| CD4 | T4 | T-cell activation, thymic differentiation and receptor for HIV |
| CD5 | T1, Tp67, LEU1 | Regulates T-cell receptor signaling |
| CD6 | T12, OX52, TP120 | T-cell activation and cell adhesion |
| CD7 | LEU 9, GP40, TP41 | T-cell interactions |
| CD8a | T8, Leu-2, MAL, CD8 alpha | Co-receptor for MHC class 1 molecules |
| CD9 | p24, MRP-1, 5H9 antigen, MIC3, TSPAN29, GIG2 | Platelet activation and aggregation, and cell adhesion and cell motility |
| CD10 | CALLA, NEP, gp100, Neprilysin, SFE, MME, EPN | Peptidase, regulates B-cell growth |
| CD11c | p150, 95, CR4, integrin αX, LFA-1A, ITGAX | Cell adhesion |
| CD18 | Integrin β2, ITGB2, MFI7 | Adhesion, cell signaling |
| CD25 | Tac, p55, IL2RA | Receptor for IL2 |
| CD26 | DPP IV, DPP4, ADABP, ADCP2 | Exoprotease. HIV pathogenesis |
| CD27 | T14, TNFRSF 7, CD27L receptor | Costimulation of B- and T-cell activation |
| CD28 | TP44, T44 | T-cell proliferation, survival, IL-2 production, and Th2 cell development |
| CD29 | Integrin β1, ITGB1, FNRB | Lymphocyte and endothelial adhesion, lymphocyte trafficking and transvascular migration |
| CD30 | Ki-1, TNFRSF8 | Regulates lymphocyte proliferation and cell death. Activation of NF-κB |
| CD31 | PECAM-1 | Cell adhesion. Plays a key role in leukocyte trafficking across endothelium |
| CD38 | T10, ADPRC1, ADP ribosyl cyclase 1 | Cell adhesion and signal transduction |
| CD39 | NTPDase 1, ENTPD1 | B-cell adhesion. Protects activated cells from lysis |
| CD40 | TNFRSF5 | Cell adhesion, cell proliferation, and signal transduction |
| CD43 | Leukosialin, sialophorin, SPN | Cell adhesion and T cell activation |
| CD44 | H-CAM, Pgp-1, Epican, HUTCH-I, LHR, ECMR-III | Cell adhesion and migration |
| CD45 | LCA, T200, B220, PTPRC | Critical for B- and T-cell receptor mediated activation. Regullar of cell growth and differentiation |
| CD47 | IAP, MER6 | Cell adhesion and signal transduction |
| CD48 | Blast-1, BCM1 | Cell adhesion and T-cell costimulation |
| CD49b | VLA-2, ITGA2 | Adhesion and platelet aggregation. |
| CD49e | VLA-5, ITGA5 | Adhesion, regulation of cell survival and apoptosis |
| CD49f | VLA-6, ITGA6 | Embryogenesis, adhesion and cell migration |
| CD50 | ICAM-3 | Adhesion and costimulation |
| CD52 | CAMPATH-1, HE5, CDW52 | Complement-mediated cell lysis and antibody-mediated cellular cytotoxicity |
| CD53 | Tetraspanin-25, MOX44 | Signal transduction. Cell adhesion, activation, and migration |
| CD54 | ICAM-1 | Cell adhesion, lymphocyte activation, and migration |
| CD55 | DAF | Regulates complement activation. Signal transduction |
| CD56 | NCAM1 | Homophilic and heterophilic adhesion |
| CD58 | LFA-3 | APC-T-cell adhesion. Killer target cell interaction. |
| CD59 | Protectin, MAC- inhibitor | Prevents complement polymerization. Protects cells from complement mediated lysis |
| CD62L | L-selectin, LECAM-1, SELL | Leukocyte rolling and homing on activated endothelium |
| CD63 | LIMP, LAMP-3, MLA1 | Cell growth and motility regulation; complexes with integrins |
| CD68 | Macrosialin, gp110, KP1 | Macrophage homing |
| CD69 | AIM, CLEC2C, EA1 | Signal transmission in NK cells and platelets |
| CD70 | Ki-24, CD27L, TNFSF7 | Induces proliferation of costimulated T-cells. Enhances the generation of cytotoxic T-cells and contributes to T-cell activation. |
| CD71 | T9, TFRC | Controls iron uptake during cell proliferation |
| CD73 | 5'-nucleotidase, NT5E | Nucleotidase |
| CD74 | LN2, Ii, DHLAG | MHC class II antigen processing |
| CD80 | B7, B7-1, BB1 | Costimulation of T-cell activation and proliferation. |
| CD82 | R2, KAI1, Tetraspanin-27 | Signal transduction |
| CD84 | SLAM5 | Homophilic adhesion molecule. Enhances T-cell activation and cytokine production |
| CD87 | UPA-R, PLAUR, MO3 | Cell chemotaxis and adhesion |
| CD90 | Thy-1 | Costimulation of lymphocytes and cell adhesion |
| CD95 | Apo-1, FASLG, APTL, TNFRSF6 | Induces apoptosis |
| CD96 | TACTILE | Involved in adhesive interactions of activated T cells and NK cells |
| CD97 | ADGRE5 | Neutrophil migration, cell adhesion and signaling |
| CD99 | MIC2, E2 | Leukocyte migration, T-cell activation and cell adhesion |
| CD100 | Semaphorin 4D, SEMA4D | Enhancement of B-cell and dendritic cell responses |
| CD106 | VCAM-1, L1CAM | Leukocyte adhesion. Transmigration and costimulation of T-cells. |
| CD107a | LAMP-1 | Cell adhesion |
| CD108 | Semaphorin 7A, SEMA7A | Monocyte activator. Negative regulator of T-cell responses. Stimulates axon growth and guidance during development |
| CD124 | IL4RA, IL4R | Receptor for IL4 and IL13 |
| CD126 | IL-6R, IL6R, gp80 | Receptor for IL6 |
| CD127 | IL-7R, IL7R | Receptor for IL7 |
| CD132 | IL2RG, Common γ | Forms complexes with other cell surface proteins including CD25, CD122, CD124, CD127 and others. Complexes with other cell surface proteins to form receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. |
| CD146 | MUC18, S-endo, MCAM | Cell adhesion. Involved in heterophilic cell to cell interactions |
| CD148 | HPTP-eta, DEP1, PTPRJ | Tyrosine phosphatase cell signaling, cell growth and differentiation, mitotic cycle and oncogenic transformation |
| CD150 | SLAM, SLAMF1, IPO-3 | Costimulation of T-cells and B-cells |
| CD151 | PETA-3, GP27, SFA-1 | Cell adhesion. |
| CD157 | BST-1 | Synthesis of cyclic ADP-ribose and putative involvement in pre-B-cell growth |
| CD161 | NKR-P1A, KLRB1 | Inhibits NK cell mediated cytotoxicity. Induces immature thymocyte proliferation |
| CD162 | PSGL-1, SELPLG | Mediates rapid rolling of leukocytes over vascular surfaces during inflammation |
| CD166 | ALCAM | Mediates cell adhesion by binding to CD6 for intrathymic T-cell development |
| CD183 | CXCR3 | T-cell chemotaxis, integrin activation, and adhesion |
| CD212 | IL-12-R β1, IL12RB1 | Forms part of the receptor complexes for IL12 and IL23 |
| CD223 | LAG-3 | Involved in lymphocyte activation, negative regulation of T-cell activation |
| CD252 | OX40L, gp34 | Ligand for receptor TNFRSF4. Co-stimulates T-cell proliferation and cytokine production |
| CD314 | NKG2D, KLRK1 | Receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells |
| CD362 | Syndecan-2, HSPG, SDC2 | Cell surface proteoglycan that bears heparan sulfate |
