CD antigens related to tumor

CD antigens or CD markers, which stands for cluster of differentiation markers, are a group of special molecules on the surface of the cells in our body. CD antigens are most useful for classifying the white blood cells (WBCs), which are the type of cell in the blood that protects us from infections. Antibodies are specifically matched against each type of CD antigen. This allows them to be used in tests to diagnose different types of lymphoma as well as being used for targeted immunotherapy. CD antigens an extremely diverse series of membrane proteins predominantly expressed on the leukocyte cell surface, and other cell types including endothelial, stem and dendritic cells. CD markers-specific antibodies have benn widely used for cell sorting, phenotyping, and blood tumor diagnosis.

The identification of tumor antigens using antibodies is a widely used strategy in cancer diagnostics, screening and research. Tumor antigens-specific antibodies can be uesd to detect elevated quantities of tumor antigens in patients' blood, urine or tissue, for tumor diagnosis and prognostic evaluation. The mostly widely accepted tumor marker of this kind is the prostate specific antigen used in the diagnosis of prostate tumor.

In addition, CD markers have become significantly important for tumor treatment. Some therapeutic antibody drugs have been designed to targen cells that have a particular type of CD marker (e.g, rituximab to CD20 for lymphomas and leukemia treatment; alemtuzumab to CD52 for chromic lymphocytic leukemia and T-cell lymphoma treatment).

CD antigens chart related to tumor

Name Alias Function
CD2 T11, LFA-2, SRBC-R, Erythrocyte receptor, LFA-3R Adhesion between T-cells and other cell types and T-cell activation.
CD31 PECAM-1 Cell adhesion. Plays a key role in leukocyte trafficking across endothelium
CD44 H-CAM, Pgp-1, Epican, HUTCH-I, LHR, ECMR-III Cell adhesion and migration
CD48 Blast-1, BCM1 Cell adhesion and T-cell costimulation
CD66a BGP-1, NCA-160, CEACAM1 Neutrophil activation, homophilic and heterophilic adhesion
CD66c NCA, CEACAM6 Cell adhesion and neutrophil activation
CD66e CEA, CEACAM5 Homophilic and heterophilic adhesion. May play a role in the metastasis of cancer cells
CD106 VCAM-1, L1CAM Leukocyte adhesion. Transmigration and costimulation of T-cells.
CD111 PVRL1, PRR1, Nectin-1, HVEC Entry mediator for several herpes viruses (HSV1, HSV2, PRV, BHV1).Believed to be involved in cell adhesion mechanisms
CD112 PVRL2, PRR2, Nectin-2, HVEB Intracellular adhesion, component of adherins junctions. Receptor for herpes simplex virus
CD144 VE-Cadherin, Cadherin-5 Cell adhesion.
CD146 MUC18, S-endo, MCAM Cell adhesion. Involved in heterophilic cell to cell interactions
CD166 ALCAM Mediates cell adhesion by binding to CD6 for intrathymic T-cell development
CD171 NCAM-L1, L1CAM Multidomain cell adhesion molecule required for normal neurohistogenesis
CD239 B-CAM, BCAM Laminin alpha-5 receptor.
CD321 JAM-A, JAM-1, PAM-1, F11R Plays a role in epithelial tight junction formation, regulation of leukocyte erythrocytes. migration, epithelial barrier maintenance and platelet activation
CD324 E-Cadherin, Uvomorulin, CDH1, E-cad Calcium-dependent cell adhesion protein

CD antigens chart as cancer biomarker

Name Alias Function
CD24 BA-1, Nectadrin Regulation of B-cell proliferation and differentiation
CD31 PECAM-1 Cell adhesion. Plays a key role in leukocyte trafficking across endothelium
CD38 T10, ADPRC1,ADP ribosyl cyclase 1 Cell adhesion and signal transduction
CD54 ICAM-1 Cell adhesion, lymphocyte activation, and migration
CD66b CD67, CGM6, CEACAM8 Cell adhesion and neutrophil activation
CD74 LN2, Ii, DHLAG MHC class II antigen processing
CD87 UPA-R, PLAUR, MO3 Cell chemotaxis and adhesion
CD96 TACTILE Involved in adhesive interactions of activated T cells and NK cells
CD98 4F2hc, SLC3A2, MDU1 Cell activation and cell aggregation
CD105 Endoglin, ENG, END Angiogenesis. Regulatory component of TGF-beta receptor complex.Modulates cellular response to TGF beta 1
CD106 VCAM-1, L1CAM Leukocyte adhesion. Transmigration and costimulation of T-cells.
CD117 c-kit, SCFR, KIT Crucial for development of gonadal and pigment stem cells
CD126 IL-6R, IL6R, gp80 Receptor for IL6
CD130 IL-6Rβ, gp130, IL6ST Transmits activities of IL6, IL11, LIF and CNF
CD138 Syndecan-1, SDC Cell proliferation, cell migration, and cell-matrix interactions
CD140b PDGFRβ, PDGFRB Cell proliferation, differentiation and survival
CD143 ACE1, DCP, DCP1, ICH, MVCD3 Converts angiotensin I to angiotensin II by release of terminal His-Leu, which results in an increase of the vasoconstrictor activity of angiotensin. Cell adhesion.
CD147 Neurothelin, basoglin, Basigin, BSG,EMMPRIN Cell adhesion and T-cell activation
CD202b Tie2, Tek Signaling, migration and adhesion
CD208 DC-LAMP, LAMP3 Dendritic cell maturation marker, involved in cell proliferation
CD221 IGF-1 R, IGF1R Receptor for IGF-I and IGF-II. Mediates mitogenic and anti-apoptotic signals
CD227 MUC1, EMA, PUM, Mucin 1 Cell adhesion and signaling
CD309 VEGFR2, KDR, FLK-1 Activation of this receptor by VEGF plays a role in angiogenesis, development, wound healing, cell proliferation, migration and differentiation
CD326 Ep-CAM, Ly74,, EGP314, TROP-1, TACSTD1 A homotypic calcium-independent T-cell adhesion molecule
CD333 FGFR3, ACH, CEK2 Cell-surface receptor for fibroblast growth factors
CD340 ERBB2, MLN 19 Binds tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways