Production of IgE antibodies promotes the development of allergic diseases such as asthma, rhinitis and atopic eczema. Production of IgE ab is dependent upon the Th2 cytokine. So Th2 cytokines play a pivotal role in the allergic disease cascade and some cytokines may serve as pivotal drug targets in allergic disease therapy.
Here the main autoimmune disease drug targets were listed included in cytokines and growth factors. And quality reagents to facilitate your research are available here.
The notion that IL-5-regulated eosinophilia plays a central role in the pathogenesis of asthma is based on extensive circumstantial evidence. The eosinophil paradigm identifies IL-5-regulated eosinophilia as a central pathogenic pathway of asthma. This led to the development therapeutic antibody.
Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of eosinophil transmigration across endothelium, mucus secretion, and differentiation of T helper type 2 lymphocytes leading to cytokine release.
The findings support a crucial role for IL-1β and inflammasome components in a variety of allergy related disorders. IL-1-neutralizing drugs have been shown to completely suppress or markedly reduce inflammatory responses in clinical studies and experimental models common allergic disorders.
Cell biology in vitro has shown that IL-9 is an important growth factor and stimulator of numerous cell types important in the pathogenesis of asthma. Mice overexpressing IL-9 and neutralizing antibodies further demonstrate a crucial role for IL-9 in the development of the allergic asthmatic response.
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