SARS-CoV

What is SARS？

SARS is Severe acute respiratory syndrome，caused by SARS-CoV. SARS can cause more severe respiratory illnesses like pneumonia with symptoms of cough (initially dry), fever, chills, fatigue, myalgia, headache. SARS first emerged in 2002, which caused 8098 people were infected with a case fatality rate of 9.6%. Different from MERS, there is no more cases reported since 2004. At the moment, no specific therapy for SARS-CoV-2, SARS-CoV, MERS-CoV and the other HCoVs infection is available. Symptomatic and supportive treatment is the mainstay of therapy for patients infected by HCoVs.

SARS-CoV

SARS-CoV belongs to Betacornavirus. The genome size of the SARS-CoV varies from 29.0 kb to 30.2 kb which can encodes structural proteins Spike, envelope (E), membrane (M), N proteins and non-structural proteins papain-like protease(s) (PLpro), chymotrypsin-likeprotease (3CLpro), RNA-dependent RNA polymerase (RdRp) and helicase (Hel). Haemagglutinin-esterase gene is absent from the genome of SARS-CoV.

The spike (S) protein is the most important antigen of SARS-CoV. It is composed of two subunits; the S1 subunit contains a receptor-binding domain (RBD) that engages with the host cell receptor angiotensin-converting enzyme 2 (ACE2) and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.
(Ref:Hayes K.H. Luka.Molecular epidemiology, evolution and phylogeny of SARS coronavirus.Infection, Genetics and Evolution.2019)

Full list of SARS-CoV Antigens

SARS-CoV Antigen
SARS-CoV Antibody

Cat#	Antigen	Expressed Host	Tag	Binding Activity
40143-V08B	Nucleocapsid	Insect	His
40634-V08B	S1+S2 ECD (577 S/A)	Insect	His	bind ACE2
40150-V08B1	S1 Subunit	Insect	His
40150-V08B1-B	S1 Subunit (Biotinylated)	Insect	His
40150-V05H1	S1 Subunit	HEK293	mFc	bind ACE2
40150-V08B2	S-RBD	Insect	His
40150-V31B2	S-RBD	Insect	rFc
40150-V05H	S-RBD	HEK293	mFc	bind ACE2
40150-V08B3	S2 subunit	Insect	His
40524-V08E	Plpro	E. coli	His

Cat#

Antigen

More

Nucleocapsid

S1+S2 ECD (577 S/A)

S1 Subunit

S1 Subunit (Biotinylated)

S1 Subunit

S-RBD

S-RBD

S-RBD

S2 subunit

Plpro

Cat#	Antigen	Ab Type	Application
40143-T62	Nucleocapsid	Rabbit PAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40143-MM05	Nucleocapsid	Mouse MAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40143-R001	Nucleocapsid	Rabbit MAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40143-RP01	Nucleocapsid	Rabbit PAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-T62-COV2	Spike	Rabbit PAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40150-MM02	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-RP01	Spike	Rabbit PAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-T52	Spike	Rabbit PAb	WB, ELISA, FCM, IP
40150-T62	Spike	Rabbit PAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40143-R004	Nucleocapsid	Rabbit MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40143-R040	Nucleocapsid	Rabbit MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40143-MM08	Nucleocapsid	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D004	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D001	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D003	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D002	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D005	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-D006	Spike	Mouse MAb	ELISA, IHC-P, FCM, ICC/IF, IP
40150-MM08	Spike	Mouse MAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP
40150-MM10	Spike	Mouse MAb	WB, ELISA, IHC-P, FCM, ICC/IF, IP