SARS-CoV-2 Variant Detection Antibodies

Since the COVID-19 outbreak, Sino Biological has been actively tracking the status of the virus to make products "up to date". We have established the largest bank of recombinant mutant proteins of spike protein, its segments (e.g., S1, RBD, S2), and nucleocapsid. We are also continuously developing specific antibodies to these mutants, neutralizing antibodies, and monoclonal antibody pairs for antigen detection.

Antibodies for the Dectecion of Nucleocapsid Mutants

Sino Biological has newly developed a series of antibodies that can detect nucleocapsid mutants found in Variants of Interest (VOIs) and Variants of Concern (VOCs).

Binding Activity by ELISA Assay (Partial List)

40588-MM123 40143-MM08 40588-MM137 40143-R004 40588-R001 Antigen Mutation Description
40588-V07E +++ +++ +++ +++ +++ Wild Type
40588-V07E1 ++++ ++++ ++++ ++++ ++++ N (R203K, G204R), discovered in many lineages
40588-V07E2 ++++ ++++ ++++ +++ ++++ N (P13L), discovered in many lineages
40588-V07E3 ++++ +++ ++++ +++ +++ N (S194L), discovered in many lineages
40588-V07E4 ++++ +++ ++++ +++ +++ N (I292T), discovered in many lineages
40588-V07E7 ++++ ++++ +++ ++++ ++++ N (D3L, R203K, G204R, S235F), found in B.1.1.7
40588-V07E8 ++++ ++++ ++++ +++ +++ N (D3L, S235F), found in B.1.1.7
40588-V07E9 ++++ ++++ ++++ ++++ ++++ N (T205I), found in B.1.351
40588-V07E11 +++ +++ ++ ++++ +++ N (P80R), found in P.1
40588-V07E19 +++ +++ +++ +++ +++ N (A12G, T205I),  found in the B.1.429 & B.1.351
40588-V07E16 +++ ++ ++ ++ ++ N (D377Y), found in B.1.617
40588-V07E20 ++++ ++++ ++++ ++++ ++++ N (R203M, D377Y), found in B.1.617, B.1.617.1
40588-V07E29 ++++ ++++ +++ ++++ ++++ N (D63G, R203M, D377Y), found in B.1.617.2
40588-V07E30 ++++ ++++ ++++ ++++ ++++ N (P67S, R203M, D377Y), found in B.1.617.3

+: Binding Capacity

Please kindly contact us for more antibodies.

Neutralizing Antibodies for the Dectecion of Spike Mutants

Neutralizing antibodies have high applicable values for diagnostic research and vaccine development. We have expanded our panel of neutralizing antibodies for the detection of spike mutants. These antibodies have differential neutralizing activities against different variants validated by Competitive ELISA Assay.

Spike Mutants Neutralizing Spike Antibodies
40150-D001 40150-D002 40591-MM43 40592-R001 40592-R118 40592-R117 40591-MM48 40592-MM135
40592-V08B | RBD
(WT)
++ ++ ++ +++ +++ +++ ++ ++
40592-V08H82 | RBD
N501Y (B.1.1.7 | Alpha Variant)
+ + ++ +++ +++ +++ - ++
40592-V08H85 | RBD
K417N, E484K, N501Y (B.1.351 | Beta Variant)
++ + ++ - - - - -
40592-V08H86 | RBD
K417T, E484K, N501Y (P.1 | Gamma Variant)
++ ++ ++ - - - - -
40592-V08H84 | RBD
E484K (Mainly exist in B.1.351 | Beta Variant)
++ ++ ++ +++ - - ++ TBD
40592-V08H88 | RBD
L452R, E484Q (B.1.617, B.1.617.1, B.1.617.3)
++ ++ ++ +++ +++ - ++ +
40592-V08H90 | RBD
L452R, T478K (B.1.617.2 | Delta Variant)
++ ++ ++ +++ +++ - - ++
40591-V08H19 | S1
E154K, E484Q, L452R, D614G, P681R (B.1.617)
++ ++ ++ +++ +++ - ++ TBD
40591-V08H17 | S1
W152C, L452R, D614G (B.1.429)
++ ++ ++ +++ +++ - ++ TBD

+: Neutralizing Capacity