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ATF2 Protein

ATF2 Protein Overview

ATF2 reagents

The cAMP response element (CRE) is an octanucleotide motif (TGACGTCA) that mediates diverse transcriptionally regulatory effects. It was first identified as an inducible enhancer of genes that can be transcribed in response to increased cAMP levels. Some growth control genes such as FOS (164810) have CRE in their transcriptional regulatory region and their expression is induced by increase in the intracellular cAMP levels. By cDNA cloning, multiple CRE-binding proteins have been identified. CREB1, originally called simply CREB (123810), was isolated by Gonzalez et al. (1989); a gene called CREB2, or CREBP1, but officially designated ATF2 (activating transcription factor-2) was cloned by Maekawa et al. (1989). All of the CRE-binding proteins have the leucine zipper structure linked to a cluster of basic amino acids in their DNA-binding domain. The regulatory element TGACGTCA is found upstream of a number of viral and cellular genes. This element has been demonstrated to mediate cyclic AMP induction of cellular genes and activation of viral genes. The CREB, or ATF, proteins bind to this motif and mediate activation by cAMP and the adenovirus E1A protein.

ATF2 protein family

Belongs to the bZIP family. ATF subfamily.

ATF2 protein name

Recommended name
Cyclic AMP-dependent transcription factor ATF-2
Short name
cAMP-dependent transcription factor ATF-2
Aliases
CRE-BP1, HB16, TREB7
Alternative name
Activating transcription factor 2 Cyclic AMP-responsive element-binding protein 2 CREB-2 cAMP-responsive element-binding protein 2 HB16 Histone acetyltransferase ATF2 cAMP response element-binding protein CRE-BP1

ATF2 Gene family protein

Basic leucine zipper proteins

ATF2 Protein Sequence

Species Human ATF2 protein
Length 505
Mass (Da) 54537
Sequence Human ATF2 protein sequence
Species Mouse ATF2 protein
Length 487
Mass (Da) 52298
Sequence Mouse ATF2 protein sequence
Species Rat ATF2 protein
Length 487
Mass (Da) 52287
Sequence Rat ATF2 protein sequence

ATF2 Protein Molecular Weight & PI

Cyclic AMP-dependent transcription factor ATF-2 (EC 2.3.1.48) (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (Histone acetyltransferase ATF2) (cAMP response element-binding protein CRE-BP1)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-505 Cyclic AMP-dependent transcription factor

Molecular weight (Da)

54537.39

Theoretical pI

7.75

ATF2 Protein Structure

Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA
Deposited
2004-04-21   Released:  2004-11-16
Deposition Author(s)
Panne, D., Maniatis, T., Harrison, S.C.
Organism(s)
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
3.0000 Å
R-Value Free
0.296
R-Value Work
0.257
1T2K From PDB

Human ATF2 protein Secondary structure

ATF2 Protein Interaction

Recombinant ATF2 Protein Feature

ATF2 Protein, Human, Recombinant (His & GST Tag)

High Purity
> 80 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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