C7 Gene Sequence, Family, Fuction and Expression Information
C7 cDNA / Gene Overview
C7 gene / cDNA is a protein-coding gene which located on 5p13.1. The C7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.215 organisms have orthologs with human gene C7.
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]
C7 cDNA / Gene Sequence
LOCUS NM_000587 5964 bp mRNA linear PRI 01-JUL-2018
Homo sapiens complement C7 (C7), mRNA.
This sequence information is just for reference only.
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