C7 Gene Sequence, Family, Fuction and Expression Information

C7 cDNA / Gene Overview

C7 gene / cDNA is a protein-coding gene which located on 5p13.1. The C7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.215 organisms have orthologs with human gene C7.

C7 cDNA / Gene Function

This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]

C7 cDNA / Gene Sequence

LOCUS
LOCUS NM_000587 5964 bp mRNA linear PRI 01-JUL-2018
DEFINITION
Homo sapiens complement C7 (C7), mRNA.
ACCESSION
NM_000587
VERSION
NM_000587.3

This sequence information is just for reference only.

C7 Family & Reagents

C7 Gene family reagents (Complement system)

Approved Symbol Reagent list
C1QB
C3
C6
CD59
CFD
CFHR1
CR2
Approved Symbol Reagent list
C2
C5
CD46
CFB
CFH
CFHR2
   

C7 Gene family reagents (Sushi domain containing)

Approved Symbol Reagent list
CFH
C2
APOH
C6
SELE
SELP
CFHR1
CFB
F13B
HP
Approved Symbol Reagent list
SEZ6L2
CR2
CD46
PAPPA2
IL15RA
CFHR2
TPO
SUSD4
CD55
IL2RA

C7 cDNA / Gene Expression

Broad expression in adrenal (RPKM 552.9), gall bladder (RPKM 224.3) and 14 other tissues