C8B Gene Sequence, Family, Fuction and Expression Information
C8B cDNA / Gene Overview
C8B cDNA / gene is a gene with protein product which located on 1p32.2. The C8B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 240 organisms have orthologs with human gene C8B.
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
C8B cDNA / Gene Sequence
HUMC8BS 1995 bp mRNA linear PRI 31-OCT-1994
Human complement protein C8 beta subunit mRNA, complete cds.
This sequence information is just for reference only.
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