C8B Gene Sequence, Family, Fuction and Expression Information

C8B cDNA / Gene Overview

C8B cDNA / gene is a gene with protein product which located on 1p32.2. The C8B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 240 organisms have orthologs with human gene C8B.

C8B cDNA / Gene Function

This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

C8B cDNA / Gene Sequence

LOCUS
HUMC8BS 1995 bp mRNA linear PRI 31-OCT-1994
DEFINITION
Human complement protein C8 beta subunit mRNA, complete cds.
ACCESSION
M16973
VERSION
M16973.1

This sequence information is just for reference only.

C8B Family & Reagents

Gene family

C8B Gene family reagents (Complement system)

Approved Symbol Reagent list
C1QB
C3
C6
CD46
CFB
CFH
CFHR2
Approved Symbol Reagent list
C2
C5
C7
CD59
CFD
CFHR1
CR2

C8B cDNA / Gene Expression

Restricted expression toward liver (RPKM 158.8)