Caspase-3 Gene Sequence, Family, Fuction and Expression Information

Caspase-3 cDNA / Gene Overview

CASP3 gene / cDNA is a protein-coding gene which located on 4q35.1. The CASP3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, mosquito, and frog.202 organisms have orthologs with human gene CASP3.

Caspase-3 cDNA / Gene Function

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]

Caspase-3 cDNA / Gene Sequence

LOCUS
LOCUS NM_004346 2689 bp mRNA linear PRI 03-JUN-2018
DEFINITION
Homo sapiens caspase 3 (CASP3), transcript variant 1, mRNA.
ACCESSION
NM_004346 NM_001354778
VERSION
NM_004346.3

This sequence information is just for reference only.

Caspase-3 Family & Reagents

Gene family

Caspase-3 Gene family reagents (Caspases)

Approved Symbol Reagent list
CASP14
Approved Symbol Reagent list
CASP7

Caspase-3 cDNA / Gene Alias

  • apopain
  • CPP32
  • CPP32B
  • Yama

Caspase-3 cDNA / Gene Expression

Ubiquitous expression in duodenum (RPKM 26.8), small intestine (RPKM 21.6) and 25 other tissues

Recombinant Caspase-3 protein citations

Title
High expression of miR-21 in triple-negative breast cancers was correlated with a poor prognosis and promoted tumor cell in vitro proliferation
Year
2014
Author
Dong, G;Liang, X;Wang, D;Gao, H;Wang, L;Wang, L;Liu, J;Du, Z;
Journal
Med. Oncol.