Caspase-3 Gene Sequence, Family, Fuction and Expression Information
Caspase-3 cDNA / Gene Overview
CASP3 gene / cDNA is a protein-coding gene which located on 4q35.1. The CASP3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, mosquito, and frog.202 organisms have orthologs with human gene CASP3.
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
Caspase-3 cDNA / Gene Sequence
LOCUS NM_004346 2689 bp mRNA linear PRI 03-JUN-2018
Homo sapiens caspase 3 (CASP3), transcript variant 1, mRNA.
This sequence information is just for reference only.
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