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CCL28: CCL28 Protein | CCL28 Antibody

CCL28 Gene family

CCL28 Background

CCL28 chemokine is expressed by epithelial cells of various mucosal tissues. This chemokine binds to CCR3 and CCR1 receptors and plays an essential role in the IgA antibody secreting cells (IgA-ASC) homing to mucosal surfaces and to lactating mammary gland as well. In addition, CCL28 has been shown to exert a potent antimicrobial activity against both Gram-negative and Gram-positive bacteria and fungi. The potent antimicrobial function of CCL28 combined with its wide distribution in mucosal tissues and secretions suggest that this protein plays an important role in innate immune protection of the epithelial surfaces. CCL28 is a human chemokine constitutively expressed by epithelial cells in diverse mucosal tissues and is known to attract a variety of immune cell types including T-cell subsets and eosinophils. Elevated levels of CCL28 have been found in the airways of individuals with asthma, and previous studies have indicated that CCL28 plays a vital role in the acute development of post-viral asthma. CCL28 presents a novel target for the development of alternative asthma therapeutics. The dental decay of children leads to the secretion of chemokine CCL28, which promotes the secretion of sIgA in saliva. CC chemokine ligand28 (CCL28) has been reported as a severity marker in atopic dermatitis.

Reference for CCL28

  • Yoon JH, et al. (2015) Ccl28 cannot replace ige for severity by objective scorad index in atopic dermatitis in children. Clin Lab 61(10), 1577-1580.
  • Liu Z, et al. (2015) [correlation between children's dental decay and the contents of saliva ccl28 and secretory immunoglobulin a]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 40(1), 102-106.
  • Thomas MA, et al. (2015) Structure-function analysis of ccl28 in the development of post-viral asthma. J Biol Chem 290(7), 4528-4536.
  • Berri M, et al. (2014) Ccl28 involvement in mucosal tissues protection as a chemokine and as an antibacterial peptide. Dev Comp Immunol 44(2), 286-290.

CCL28 Protein

CCL28 protein function

Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.

CCL28 protein expression

Tissue specificity

Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.

CCL28 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    127.00
  • Mass (Da)
    14.00

CCL28 Antibody

There are 3 CCL28 antibodies which are validated in multiple tissues with various applications, including ELISA. There are 3 CCL28 antibody for ELISA. Among all these CCL28 antibodies, there are 1 anti-CCL28 mouse monoclonal antibodies , 1 anti-CCL28 rabbit monoclonal antibodies , 1 anti-CCL28 rabbit polyclonal antibodies . All the CCL28 anbodies are produced in house and all are in stock. CCL28 antibody customerized service is available.

CCL28 Gene

CCL28 gene / cDNA is a protein-coding gene which located on 5p12. The CCL28 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.167 organisms have orthologs with human gene CCL28.