CD11c/ITGAX Gene Sequence, Family, Fuction and Expression Information

CD11c/ITGAX cDNA / Gene Overview

ITGAX cDNA / gene is a gene with protein product which located on 16p11.2. The ITGAX gene is conserved in chimpanzee, dog, mouse, and rat. 87 organisms have orthologs with human gene ITGAX.

CD11c/ITGAX cDNA / Gene Function

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

CD11c/ITGAX cDNA / Gene Sequence

LOCUS
BC038237 4042 bp mRNA linear PRI 06-JUN-2006
DEFINITION
Homo sapiens integrin, alpha X (complement component 3 receptor 4 subunit), mRNA (cDNA clone MGC:46124 IMAGE:5745308), complete cds.
ACCESSION
BC038237
VERSION
BC038237.1

This sequence information is just for reference only.

CD11c/ITGAX Family & Reagents

CD11c/ITGAX Gene family reagents (CD molecules)

Approved Symbol Reagent list
TNFRSF10D
SIRPA
L1CAM
THY1
CD209
LAMP3
PROM1
TNFSF4
SELL
SLAMF1
Approved Symbol Reagent list
SLAMF7
IL4R
JAG1
PLAUR
FCGR2A
CLEC7A
CDCP1
CD55
EpCAM
BCAM

CD11c/ITGAX Gene family reagents (Complement system)

Approved Symbol Reagent list
C1QB
C3
C6
CD46
CFB
CFH
CFHR2
Approved Symbol Reagent list
C2
C5
C7
CD59
CFD
CFHR1
CR2

CD11c/ITGAX cDNA / Gene Alias

  • CD11c
  • complement component 3 receptor 4 subunit

CD11c/ITGAX cDNA / Gene Expression

Biased expression in spleen (RPKM 34.3), appendix (RPKM 32.4) and 12 other tissues