CD11c/ITGAX Protein Overview: Sequence, Structure, Function and Protein Interaction

CD11c/ITGAX Protein Overview

Leukocyte surface antigen p150,95 shares a beta subunit (600065) with 2 other members of the leukocyte adhesion molecule family (120980, 153370) but has a unique alpha chain. Corbi et al. (1987) cloned and sequenced the gene for the alpha subunit of p150,95. The 4.7-kb cDNA clone encodes a signal sequence, an extracellular domain of 1,081 amino acids containing 10 potential glycosylation sites, a transmembrane domain of 26 amino acids, and a C-terminal cytoplasmic tail of 29 residues. It shows homology to the alpha subunits of platelet glycoprotein IIb/IIIa (607759), vitronectin receptor (193210), and fibronectin (135620) receptor. The receptors involved in both cell-cell and cell-matrix interactions appear to belong to a single superfamily of genes termed the integrins.

CD11c/ITGAX protein family

Belongs to the integrin alpha chain family.

CD11c/ITGAX protein name

Recommended name
Integrin alpha-X
Aliases
CD11c, complement component 3 receptor 4 subunit

CD11c/ITGAX Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 20-1163 Integrin alpha-X.

Molecular weight (Da)

125839.8

Theoretical pI

6.08

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