CD20 Protein

CD20 Protein Overview

CD20 reagents

The MS4A1 gene encodes a member of the MS4A family of proteins that share structural similarity, amino acid sequence homology, and chromosomal location. MS4A proteins contain 4 highly conserved transmembrane domains, flanked by N- and C-terminal cytoplasmic regions. MS4A1, also known as CD20 or B1, is a human B-lymphocyte surface molecule that is widely expressed during B-cell ontogeny, from early pre-B-cell developmental stages until final differentiation into plasma cells. Functional studies using monoclonal antibodies have shown that antibody binding to B1 inhibits B-cell proliferation caused by mitogens and inhibits B-cell differentiation. Tedder et al. (1988) described the primary structure of CD20.

CD20 protein family

Belongs to the MS4A family.

CD20 protein name

Recommended name
B-lymphocyte antigen CD20
Aliases
B1, Bp35, MS4A2
Alternative name
B-lymphocyte surface antigen B1 Bp35 Leukocyte surface antigen Leu-16 Membrane-spanning 4-domains subfamily A member 1 CD_antigen: CD20

CD20 Protein Sequence

Species Human CD20 protein
Length 297
Mass (Da) 33077
Sequence Human CD20 protein sequence
Species Mouse CD20 protein
Length 291
Mass (Da) 31958
Sequence Mouse CD20 protein sequence
Species
Length
Mass (Da)
Sequence

CD20 Protein Molecular Weight & PI

B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD20 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-297 B-lymphocyte antigen CD20.

Molecular weight (Da)

33077.32

Theoretical pI

5.04

CD20 Protein Structure

Crystal structure of Rituximab Fab in complex with an epitope peptide
Deposited
2007-02-06   Released:  2007-04-10
Deposition Author(s)
Du, J., Zhong, C., Ding, J.
Organism(s)
Homo sapiens
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.6000 Å
R-Value Free
0.296
R-Value Work
0.239
2OSL From PDB

Human CD20 protein Secondary structure

CD20 Protein Interaction

Recombinant CD20 Protein Feature

CD20 Protein, Human, Recombinant (TrxA Tag)

High Purity
> 80 % as determined by SDS-PAGE.
Low Endotoxin
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