CD31 Information: CD31 Protein, CD31 Antibody and CD31 Gene

CD31 Gene family

CD31 Protein

CD31 protein function

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; Isoform Delta15: Does not protect against apoptosis. {ECO:0000269|PubMed:18388311}.

CD31 protein expression

Tissue specificity

Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580308). Expressed on neutrophils (at protein level) (PubMed:17580308). Isoform Long predominates in all tissues examined (PubMed:12433657). Isoform Delta12 is detected only in trachea (PubMed:12433657). Isoform Delta14-15 is only detected in lung (PubMed:12433657). Isoform Delta14 is detected in all tissues examined with the strongest expression in heart (PubMed:12433657). Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level) (PubMed:12433657, PubMed:18388311).

CD31 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

CD31 Antibody

There are 26 CD31 antibodies which are validated in multiple tissues with various applications, including FCM, ELISA(Cap), ELISA(Det), ICC/IF, IHC-P, ELISA, WB, IP. There are 13 CD31 antibody for FCM, 1 CD31 antibody for ELISA(Cap), 1 CD31 antibody for ELISA(Det), 3 CD31 antibody for ICC/IF, 8 CD31 antibody for IHC-P, 7 CD31 antibody for ELISA, 2 CD31 antibody for WB, 2 CD31 antibody for IP. Among all these CD31 antibodies, there are 13 anti-CD31 mouse monoclonal antibodies , 9 anti-CD31 rabbit monoclonal antibodies , 4 anti-CD31 rabbit polyclonal antibodies . All the CD31 anbodies are produced in house and all are in stock. CD31 antibody customerized service is available.

CD31 Gene

PECAM1 gene / cDNA is a protein-coding gene which located on 17q23.3. The PECAM1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.191 organisms have orthologs with human gene PECAM1.