CD31 Gene Sequence, Family, Fuction and Expression Information

CD31 cDNA / Gene Overview

PECAM1 gene / cDNA is a protein-coding gene which located on 17q23.3. The PECAM1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.191 organisms have orthologs with human gene PECAM1.

CD31 cDNA / Gene Function

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

CD31 cDNA / Gene Sequence

LOCUS
LOCUS NM_000442 6831 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens platelet and endothelial cell adhesion molecule 1 (PECAM1), mRNA.
ACCESSION
NM_000442 XR_108267 XR_109420
VERSION
NM_000442.4

This sequence information is just for reference only.

CD31 Family & Reagents

CD31 Gene family reagents (CD molecules)

Approved Symbol Reagent list
CD28
IL2RA
FZD10
CD58
KIR2DL5A
IGSF8
CD68
NECTIN1
BST1
CDH1
Approved Symbol Reagent list
IL10RB
IL17RA
ICAM3
CD40LG
NRP1
ICAM4
CD55
FCGR3A
ICOS
CD27

CD31 Gene family reagents (Immunoglobulin like domain containing)

Approved Symbol Reagent list
F11R
HEPACAM
IL11RA
MDGA2
FCAR
VSIG4
CXADR
IL1RAP
KIT
ICAM1
Approved Symbol Reagent list
IL12B
IL1R1
CD19
CSF1R
FCMR
FLT4
NECTIN1
IL18RAP
IL6R
FCRL2

CD31 Gene family reagents (Ig-like cell adhesion molecule family)

Approved Symbol Reagent list
MCAM
CD96
NCAM1
SLAMF6
VCAM1
CNTN3
CD58
ICAM4
CNTN1
ROBO2
Approved Symbol Reagent list
UNC5A
L1CAM
PVR
LILRB2
SIRPA
CNTN5
CRTAM
HEPACAM
SIRPG
JAM2

CD31 cDNA / Gene Alias

  • CD31
  • CD31 antigen

CD31 cDNA / Gene Expression

Broad expression in placenta (RPKM 145.1), lung (RPKM 87.5) and 19 other tissues

Recombinant CD31 protein citations

Title
Barbigerone, an isoflavone, inhibits tumor angiogenesis and human non-small-cell lung cancer xenografts growth through VEGFR2 signaling pathways
Year
2012
Author
Li, X;Wang, X;Ye, H;Peng, A;Chen, L;
Journal
Cancer Chemother. Pharmacol.
Title
Gambogic acid exhibits anti-psoriatic efficacy through inhibition of angiogenesis and inflammation
Year
2014
Author
Wen, J;Pei, H;Wang, X;Xie, C;Li, S;Huang, L;Qiu, N;Wang, W;Cheng, X;Chen, L;
Journal
J. Dermatol. Sci.
Title
2, 5-Dihydro-2, 5-dimethoxyfuran crosslinked silk-chitosan blend tubular construct for vascular graft application
Year
2016
Author
Pawar, HS;Francis, NK;Rameshbabu, AP;Dhara, S;
Journal
Materials Today Communications