CDC42 Gene Sequence, Family, Fuction and Expression Information

CDC42 cDNA / Gene Overview

CDC42 gene / cDNA is a protein-coding gene which located on 1p36.12. The CDC42 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.198 organisms have orthologs with human gene CDC42.

CDC42 cDNA / Gene Function

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

CDC42 cDNA / Gene Sequence

LOCUS
LOCUS NM_001791 2182 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens cell division cycle 42 (CDC42), transcript variant 1, mRNA.
ACCESSION
NM_001791
VERSION
NM_001791.3

This sequence information is just for reference only.

CDC42 Family & Reagents

Gene family

CDC42 Gene family reagents (Rho family GTPases)

Approved Symbol Reagent list
RAC1
RHOA
Approved Symbol Reagent list
RAC2
   

CDC42 cDNA / Gene Alias

  • CDC42Hs
  • G25K
  • GTP binding protein
  • 25kDa

CDC42 cDNA / Gene Expression

Ubiquitous expression in bone marrow (RPKM 88.8), colon (RPKM 72.7) and 25 other tissues