CDC42 Protein Overview: Sequence, Structure, Function and Protein Interaction

CDC42 Protein Overview

CDC42 is a Ras (see 190020)-related GTP-binding protein. It is implicated in a variety of biologic activities, including establishment of cell polarity in yeast, regulation of cell morphology, motility, and cell cycle progression in mammalian cells, and induction of malignant transformation (summary by Wu et al., 2000).

CDC42 protein family

Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.

CDC42 protein name

Recommended name
Cell division control protein 42 homolog
CDC42Hs, G25K, GTP binding protein, 25kDa
Alternative name
G25K GTP-binding protein

CDC42 Gene family protein

Rho family GTPases

CDC42 Protein Sequence

Species Human CDC42 protein
Length 191
Mass (Da) 21259
Sequence Human CDC42 protein sequence
Species Mouse CDC42 protein
Length 191
Mass (Da) 21259
Sequence Mouse CDC42 protein sequence
Species Rat CDC42 protein
Length 191
Mass (Da) 21259
Sequence Rat CDC42 protein sequence

CDC42 Protein Molecular Weight & PI

Cell division control protein 42 homolog precursor (G25K GTP-binding protein) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-188 Cell division control protein 42 homolog.

Molecular weight (Da)


Theoretical pI


CDC42 Protein Structure

The Structural Basis for Cdc42-Induced Dimerization of IQGAPs
2015-07-14   Released:  2016-08-10
Deposition Author(s)
Worthylake, D.K., Boyapati, V.K., LeCour Jr, L.
Homo sapiens
Expression System
Escherichia coli BL21
Experimental Data Snapshot
2.6000 Å
R-Value Free
R-Value Work

Human CDC42 protein Secondary structure

CDC42 Protein Interaction

Recombinant CDC42 Protein Feature

CDC42 Protein, Human, Recombinant (GST Tag)

High Purity
> 85 % as determined by SDS-PAGE
Low Endotoxin
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