CDK4 Gene Sequence, Family, Fuction and Expression Information

CDK4 cDNA / Gene Overview

CDK4 gene / cDNA is a protein-coding gene which located on 12q14.1. The CDK4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.171 organisms have orthologs with human gene CDK4.

CDK4 cDNA / Gene Function

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

CDK4 cDNA / Gene Sequence

LOCUS
LOCUS NM_000075 2020 bp mRNA linear PRI 22-JUL-2018
DEFINITION
Homo sapiens cyclin dependent kinase 4 (CDK4), mRNA.
ACCESSION
NM_000075 NM_032913
VERSION
NM_000075.3

This sequence information is just for reference only.

CDK4 Family & Reagents

CDK4 Gene family reagents (Cyclin dependent kinases)

Approved Symbol Reagent list
CDK1
CDK2
CDKL2
Approved Symbol Reagent list
CDK16
CDK5
   

CDK4 cDNA / Gene Alias

  • PSK-J3

CDK4 cDNA / Gene Expression

Ubiquitous expression in ovary (RPKM 36.9), endometrium (RPKM 35.9) and 25 other tissues