CDK7 Information: CDK7 Protein, CDK7 Antibody and CDK7 Gene

CDK7 Gene family

CDK7 Protein

CDK7 protein function

Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.

CDK7 protein expression

Tissue specificity

Ubiquitous.

Induction

Repressed by DNA-bound peptides.

CDK7 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    346.00
  • Mass (Da)
    39.00

CDK7 Antibody

There are 1 CDK7 antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, ICC/IF. There are 1 CDK7 antibody for WB, 1 CDK7 antibody for IHC-P, 1 CDK7 antibody for ICC/IF. Among all these CDK7 antibodies, there are 1 anti-CDK7 rabbit polyclonal antibodies . All the CDK7 anbodies are produced in house and all are in stock. CDK7 antibody customerized service is available.

CDK7 Gene

CDK7 cDNA / gene is a gene with protein product which located on 5q13.2. The CDK7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog. 237 organisms have orthologs with human gene CDK7.