CDK7 Protein Overview: Sequence, Structure, Function and Protein Interaction

CDK7 Protein Overview

CDK7 reagents

Levedakou et al. (1994) used degenerate PCR to clone a novel serine/threonine protein kinase which they termed STK1. Levedakou et al. (1994) cloned the STK1 cDNA from a human breast carcinoma cell line; the gene encodes a 346-amino acid polypeptide. Based on amino acid sequence analysis, Levedakou et al. (1994) considered STK1 to be the human homolog of Xenopus MO15, a cell cycle-associated kinase. Northern blot analysis revealed that the STK1 gene is expressed as an mRNA of 1.4 kb in heart and several other tissues. Levedakou et al. (1994) noted that levels of STK1 mRNA remain invariant throughout the cell cycle.

CDK7 protein family

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

CDK7 protein name

Recommended name
Cyclin-dependent kinase 7
Aliases
CAK, CAK1, CDKN7, MO15, STK1

CDK7 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 2-346 Cyclin-dependent kinase 7.

Molecular weight (Da)

38907.21

Theoretical pI

8.67

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