CDK8 Gene Sequence, Family, Fuction and Expression Information

CDK8 cDNA / Gene Overview

CDK8 cDNA / gene is a gene with protein product which located on 13q12.13. The CDK8 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog. 228 organisms have orthologs with human gene CDK8.

CDK8 cDNA / Gene Function

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

CDK8 cDNA / Gene Sequence

LOCUS
X85753 1772 bp mRNA linear PRI 07-OCT-2008
DEFINITION
Homo sapiens mRNA for CDK8 protein kinase.
ACCESSION
X85753
VERSION
X85753.1

This sequence information is just for reference only.

CDK8 Family & Reagents

CDK8 Gene family reagents (Cyclin dependent kinases)

Approved Symbol Reagent list
CDK1
CDK2
CDK5
Approved Symbol Reagent list
CDK16
CDK4
CDKL2

CDK8 cDNA / Gene Alias

  • K35

CDK8 cDNA / Gene Expression

Ubiquitous expression in testis (RPKM 6.1), duodenum (RPKM 3.9) and 25 other tissues