CDK8 Protein Overview: Sequence, Structure, Function and Protein Interaction

CDK8 Protein Overview

CDK8 reagents

To identify human protein kinases with a role in cell cycle control, Schultz and Nigg (1993) performed PCR with degenerate oligonucleotides based on conserved motifs in the catalytic domain of the Aspergillus nidulans NIMA protein kinase. They isolated 41 distinct promyelocytic leukemia cell line cDNAs, including 1 partial cDNA designated K35. Tassan et al. (1995) noted that K35 appears to be structurally related to cyclin-dependent kinases (CDKs). By screening a human testis cDNA library with K35, they isolated cDNAs corresponding to the entire coding region of CDK8. The predicted 464-amino acid protein contains the sequence motifs and 11 subdomains characteristic of a serine/threonine-specific kinase. The protein sequence of CDK8 shares 48% identity over subdomains III to XI with the S. cerevisiae CDK SRB10, and the 2 proteins have several common features. CDK8 migrated as a 53-kD protein on Western blots of HeLa cell extracts.

CDK8 protein family

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

CDK8 protein name

Recommended name
Cyclin-dependent kinase 8

CDK8 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 1-464 Cyclin-dependent kinase 8.

Molecular weight (Da)


Theoretical pI


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