CEACAM5 Protein Overview: Sequence, Structure, Function and Protein Interaction

CEACAM5 Protein Overview

Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (109770).

CEACAM5 protein family

Belongs to the immunoglobulin superfamily. CEA family.

CEACAM5 protein name

Recommended name
Carcinoembryonic antigen-related cell adhesion molecule 5
Aliases
CD66e
Alternative name
Carcinoembryonic antigen CEA Meconium antigen 100 CD antigen CD66e

CEACAM5 Gene family protein

Carcinoembryonic antigen related cell adhesion molecule family

CEACAM5 Protein Sequence

Species Human CEACAM5 protein
Length 702
Mass (Da) 76795
Sequence Human CEACAM5 protein sequence
Species Mouse CEACAM5 protein
Length 947
Mass (Da) 106270
Sequence Mouse CEACAM5 protein sequence
Species
Length
Mass (Da)
Sequence

CEACAM5 Protein Molecular Weight & PI

Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 35-685 Carcinoembryonic antigen-related cell

Molecular weight (Da)

71328.14

Theoretical pI

5.44

CEACAM5 Protein Structure

Crystal structure of the N-terminal domain of carcinoembryonic antigen (CEA)
Deposited
2007-07-31   Released:  2008-01-01
Deposition Author(s)
Le Trong, I., Korotkova, N., Moseley, S.L., Stenkamp, R.E.
Organism(s)
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
1.9500 Å
R-Value Free
0.203
R-Value Work
0.180
2QSQ From PDB

Human CEACAM5 protein Secondary structure

CEACAM5 Protein Interaction

Recombinant CEACAM5 Protein Feature

CEACAM5 Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant CEACAM5 protein citations

Title
Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Year
2016
Author
Chan, CM;Chu, H;Wang, Y;Wong, BH;Zhao, X;Zhou, J;Yang, D;Leung, SP;Chan, JF;Yeung, ML;Yan, J;Lu, G;Gao, GF;Yuen, KY;
Journal
J. Virol.
Title
Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs
Year
2016
Author
Javaheri, A;Kruse, T;Moonens, K;Luque, RM;Debraekeleer, A;Asche, CI;Tegtmeyer, N;Kalali, B;Bach, NC;Sieber, SA;Hill, DJ;Königer, V;Hauck, CR;Moskalenko, R;Haas, R;Busch, DH;Klaile, E;Slevogt, H;Schmidt, A;Backert, S;Remaut, H;Singer, BB;Gerhard, M;
Journal
Nature microbiology
Title
Protein binding-protected DNA three-way junction-mediated rolling circle amplification for sensitive and specific detection of transcription factors
Year
2016
Author
Li, K;Wang, L;Xu, X;Gao, T;Yan, P;Jiang, W;
Journal
RSC Advances
Title
Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells
Year
2017
Author
Klaile, E;Müller, MM;Schäfer, MR;Clauder, AK;Feer, S;Heyl, KA;Stock, M;Klassert, TE;Zipfel, PF;Singer, BB;Slevogt, H;
Journal
MBio
Title
Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA(+) Metastatic Colorectal Cancers
Year
2017
Author
Zhang, C;Wang, Z;Yang, Z;Wang, M;Li, S;Li, Y;Zhang, R;Xiong, Z;Wei, Z;Shen, J;Luo, Y;Zhang, Q;Liu, L;Qin, H;Liu, W;Wu, F;Chen, W;Pan, F;Zhang, X;Bie, P;Liang, H;Pecher, G;Qian, C;
Journal
Mol. Ther

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