CMV Glycoprotein B Protein Overview: Sequence, Structure, Function and Protein Interaction

CMV Glycoprotein B Protein Overview

CMV Glycoprotein B reagents

The CFB gene encodes complement factor B, which is part of the alternative complement pathway. Complement factor B is cleaved into a 30-kD N terminal 'Ba' fragment and a 57-kD C-terminal 'Bb' fragment by factor D (CFD; 134350) in the presence of C3b. The C-terminal half of the Bb fragment contains the essential active site residues characteristic of serine proteases, but has a molecular weight twice that of proteinases previously described, suggesting that it is a novel type of serine proteinase. The Bb fragment forms the C3bBb alternative pathway convertase (Christie and Gagnon, 1983). Complement factor B was originally known as a glycine-rich beta-glycoprotein (GBG).

Recombinant CMV Glycoprotein B Protein Feature

Human cytomegalovirus (HCMV) Glycoprotein B / gB Protein (His Tag)

High Purity
> 70 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant CMV Glycoprotein B protein citations

Title
Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus
Year
2012
Author
Fu TM, Wang D, Freed DC, Tang A, Li F, He X, Cole S, Dubey S, Finnefrock AC, ter Meulen J, Shiver JW, Casimiro DR.
Journal
Vaccine
Title
Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine
Year
2013
Author
Freed DC, Tang Q, Tang A, Li F, He X, Huang Z, Meng W, Xia L, Finnefrock AC, Durr E, Espeseth AS, Casimiro DR, Zhang N, Shiver JW, Wang D, An Z, Fu TM
Journal
Proc. Natl. Acad. Sci. U.S.A.
Title
Enveloped Virus-Like Particle Expression of Human Cytomegalovirus Glycoprotein B Antigen Induces Antibodies with Potent and Broad Neutralizing Activity
Year
2014
Author
M Kirchmeier, AC Fluckiger, C Soare…
Journal
Clinical and Vaccine Immunology
Title
A replication-defective human cytomegalovirus vaccine for prevention of congenital infection
Year
2016
Author
Wang, D;Freed, DC;He, X;Li, F;Tang, A;Cox, KS;Dubey, SA;Cole, S;Medi, MB;Liu, Y;Xu, J;Zhang, ZQ;Finnefrock, AC;Song, L;Espeseth, AS;Shiver, JW;Casimiro, DR;Fu, TM;
Journal
Sci Transl Med
Title
Additive Protection against Congenital CMV Conferred by Combined gB/pp65 Vaccination using a Lymphocytic Choriomeningitis Virus (LCMV) Vector
Year
2016
Author
Schleiss, MR;Berka, U;Watson, E;Aistleithner, M;Kiefmann, B;Mangeat, B;Swanson, EC;Gillis, PA;Hernandez-Alvarado, N;Fernández-Alarcón, C;Zabeli, JC;Pinschewer, DD;Lilja, A;Schwendinger, M;Guirakhoo, F;Monath, TP;Orlinger, K;
Journal
Clin. Vaccine Immunol.
Title
Additive Protection against Congenital CMV Conferred by Combined gB/pp65 Vaccination using a Lymphocytic Choriomeningitis Virus (LCMV) Vector
Year
2016
Author
Schleiss, MR;Berka, U;Watson, E;Aistleithner, M;Kiefmann, B;Mangeat, B;Swanson, EC;Gillis, PA;Hernandez-Alvarado, N;Fernández-Alarcón, C;Zabeli, JC;Pinschewer, DD;Lilja, A;Schwendinger, M;Guirakhoo, F;Monath, TP;Orlinger, K;
Journal
Clin. Vaccine Immunol.
Title
BiTE Antikörper-Konstrukte zur Therapie von Influenza A-und Cytomegalovirus-Infektionen
Year
2016
Author
Pendzialek, DBJ;
Journal
Thesis
Title
Genetic markers of immunoglobulin G and immunity to cytomegalovirus in patients with breast cancer
Year
2016
Author
Pandey, JP;Namboodiri, AM;Mohan, S;Nietert, PJ;Peterson, L;
Journal
Cell. Immunol.
Title
Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity
Year
2018
Author
John, S;Yuzhakov, O;Woods, A;Deterling, J;Hassett, K;Shaw, CA;Ciaramella, G;
Journal
Vaccine
Title
Novel trimeric human cytomegalovirus glycoprotein B elicits a high-titer neutralizing antibody response
Year
2018
Author
Cui, X;Cao, Z;Wang, S;Lee, RB;Wang, X;Murata, H;Adler, SP;McVoy, MA;Snapper, CM;
Journal
Vaccine

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