CSK Information: CSK Protein, CSK Antibody and CSK Gene

CSK Gene family

CSK Protein

CSK protein function

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}.

CSK protein expression

Tissue specificity

Expressed in lung and macrophages.

CSK protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    450.00
  • Mass (Da)
    50.00

CSK Antibody

There are 2 CSK antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, IP, ELISA. There are 2 CSK antibody for WB, 1 CSK antibody for IHC-P, 1 CSK antibody for IP, 1 CSK antibody for ELISA. Among all these CSK antibodies, there are 2 anti-CSK rabbit polyclonal antibodies . All the CSK anbodies are produced in house and all are in stock. CSK antibody customerized service is available.

CSK Gene

CSK gene / cDNA is a protein-coding gene which located on 15q24.1. The CSK gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, C.elegans, and frog.214 organisms have orthologs with human gene CSK.