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CXCL5: CXCL5 Protein | CXCL5 Antibody

CXCL5 Gene family

CXCL5 Background

CXCL5 is a small cytokine belonging to the CXC chemokine family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL5 is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. It also can be detected in eosinophils, and can be inhibited with the type II interferon. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which can be utilized to understand more about pain in other inflammatory conditions like arthritis and cystitis. It stimulates the chemotaxis of neutrophils possesses angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.

Reference for CXCL5

  • Dawes JM, et al. (2011) CXCL5 Mediates UVB Irradiation-Induced Pain. Sci Transl Med. 3(90): 90ra60.
  • O'Donovan N, et al. (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84(1-2):39-42.
  • Persson T, et al. (2003) Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils. Clin Exp Allergy. 33(4):531-7.

CXCL5 Protein

CXCL5 protein function

Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. {ECO:0000269|PubMed:10095777}.

CXCL5 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

CXCL5 Antibody

There are 7 CXCL5 antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), ELISA, ELISA(Det), IHC-P, WB. There are 1 CXCL5 antibody for ELISA(Cap), 3 CXCL5 antibody for ELISA, 1 CXCL5 antibody for ELISA(Det), 2 CXCL5 antibody for IHC-P, 1 CXCL5 antibody for WB. Among all these CXCL5 antibodies, there are 3 anti-CXCL5 mouse monoclonal antibodies , 4 anti-CXCL5 rabbit polyclonal antibodies . All the CXCL5 anbodies are produced in house and all are in stock. CXCL5 antibody customerized service is available.

CXCL5 Gene

CXCL5 gene / cDNA is a protein-coding gene which located on 4q13.3. The CXCL5 gene is conserved in chimpanzee, Rhesus monkey, and cow.17 organisms have orthologs with human gene CXCL5.