CXCR4/CD184 Information: CXCR4/CD184 Protein, CXCR4/CD184 Antibody and CXCR4/CD184 Gene

CXCR4/CD184 Gene family

CXCR4/CD184 Protein

CXCR4/CD184 protein function

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

CXCR4/CD184 protein expression

Tissue specificity

Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.

Induction

(Microbial infection) May be down-regulated by Human cytomegalovirus/HHV-5.

CXCR4/CD184 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    352.00
  • Mass (Da)
    39.00

CXCR4/CD184 Antibody

There are 1 CXCR4/CD184 antibodies which are validated in multiple tissues with various applications, including WB, IP. There are 1 CXCR4/CD184 antibody for WB, 1 CXCR4/CD184 antibody for IP. Among all these CXCR4/CD184 antibodies, there are 1 anti-CXCR4/CD184 rabbit polyclonal antibodies . All the CXCR4/CD184 anbodies are produced in house and all are in stock. CXCR4/CD184 antibody customerized service is available.

CXCR4/CD184 Gene

CXCR4 cDNA / gene is a gene with protein product which located on 2q22.1. The CXCR4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 231 organisms have orthologs with human gene CXCR4.