Growth Factor Receptors

Growth factor receptors are transmembrane proteins which bind to specific growth factors and transmit the instructions conveyed by the factors to intracellular space. The growth factor receptors on cell surface are very common, and cells mainly contains receptors for several growth factors. Most receptors have a cysteine-rich region, which participate in signal transduction by receptor tyrosine kinase, e.g., the receptors fibroblast growth factor, vascular endothelial growth factor, epidermal growth factor, insulin-like growth factor, and platelet-derived growth factor, etc. Meanwhile, there are some receptors which mediate the signal transduction via receptor serine-threonine kinase, such as the receptor for transforming growth factor β.

References

Narla ST, et al. (2013) Activation of Developmental Nuclear Fibroblast Growth Factor Receptor 1 Signaling and Neurogenesis in Adult Brain by α7 Nicotinic Receptor Agonist. Stem Cells Transl Med. [Epub ahead of print].
Galazios G, et al. (2009) Vascular endothelial growth factor gene polymorphisms and pregnancy. J Matern Fetal Neonatal Med. 22(5):371-8.
Fiore M, et al. (2009) Nerve growth factor as a signaling molecule for nerve cells and also for the neuroendocrine-immune systems. Rev Neurosci. 20(2):133-45.