Sino Biological - 공식 웹사이트

EDA2R: EDA2R Protein | EDA2R Antibody

EDA2R Gene family

EDA2R Background

Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).

Reference for EDA2R

  • Yan M., et al., 2000,Science. 290: 523-527.
  • Sinha S.K., et al., 2002, J. Biol. Chem. 277: 44953-44961.
  • Prodi, D.A. et al., 2008, J Invest Dermatol128(9):2268-70.

EDA2R Protein

EDA2R protein function

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. {ECO:0000269|PubMed:12270937}.

EDA2R protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    297.00
  • Mass (Da)
    32.00

EDA2R Antibody

There are 5 EDA2R antibodies which are validated in multiple tissues with various applications, including ELISA. There are 5 EDA2R antibody for ELISA. Among all these EDA2R antibodies, there are 1 anti-EDA2R mouse monoclonal antibodies , 1 anti-EDA2R rabbit monoclonal antibodies , 3 anti-EDA2R rabbit polyclonal antibodies . All the EDA2R anbodies are produced in house and all are in stock. EDA2R antibody customerized service is available.

EDA2R Gene

EDA2R gene / cDNA is a protein-coding gene which located on Xq12. The EDA2R gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, and frog.168 organisms have orthologs with human gene EDA2R.